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KMID : 0877219970010010129
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Journal of Korean Epilepsy Society
1997 Volume.1 No. 1 p.129 ~ p.134
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Clinical Significance of Cerebrospinal Fluid Pleocytosis in Acute Stage after Seizures
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Kim Jang-Sung
Park Sun-Ah
Huh Kyoon
Kim Sung-Hwan
Lee Byung-In
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Abstract
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Purpose : The cerebrospinal fluid (CSF) examination is regarded as a standard neurological practice for the initial evaluation and management of acute onset seizures. However, the incidence and clinical significance of CSFP, particularly in the context of etiological assessment, has not been well addressed yet in this country. We analyzed the CSF data and clinical features of the patients presented with acute seizure, in attempt to delineate possible guideline in interpretation of CSF profile.
Methods : We selected 95 seizure patients who underwent CSF study within 24 hours of a seizure. Febrile seizure, pseudoseizure, and the seizures due to definitive preexisting etiology for CSFP were excluded. Clinical characteristics, including sex, age, CSF profiles, EEG findings, etiology and type of seizure and seizure frequency during the first 24 hours, were compared and analyzed 1) between the groups with and without CSFP. 2) between a first seizure patients and epilepsy patients, and 3) between the groups with and without CSFP in a first seizure patients.
Results : Among 95 patients, 1) 23 patients (24.2%) showed CSFP, 2) CSFP was present in 73.3% of the patients with infectious etiology, whereas 11.8% of the patient without infection showed CSFP, 3) CSFP was significantly more frequent in the patient with a first seizure (34.6%) as compared to the patient tilth epilepsy (11.6%), 4) infectious etiology was significantly more common in the patients with a first seizure (30.6%) as compared to the patient with epilepsy (11.6%) 5) In the patients with a first seizure, CSFP was predominant1y associated with infectious etiology (72.2%). but 8.8% of the patients without CSFP were turned out to have infectious etiology.
Conclusion : These results support the notion that CSFP may be highly related to infectious etiology in acute seizures, particularly in 3 first seizure. Small number of patients without infection may show CSFP, however CSF profile should not be used as a sole criteria of assement of infectious etiology of the seizure.
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KEYWORD
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CSF pleocytosis, A first seizure, Epilepsy, Infectious etiology
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